However, for experiments focusing on immunological reactions towards the prospective source of ECs, such as MHC-silenced ECs [22] or iPS-ECs [21], and also in parallel to specific lung injury models to mimic and investigate gas exchange capacities in patients with end-lung diseases, BHL testing in an allogeneic animal model, especially for long-term performance, is mandatory. This evidence concerns the gene HLA-C and lung disorder.