Meanwhile, the latest research results of Ahmad et al. suggest that LRRC8A plays an important role in maintaining vascular function by regulating the Akt-eNOS signaling pathway in vascular endothelial cells, and knockout of LRRC8A can lead to insulin resistance and damage vascular function by interfering with the PI3K-Akt-eNOS pathway [33]. Here, AKT1 is linked to Insulin resistance.