As an example, diminished HLA-DR expression on circulating monocytes and a reduced capacity of blood leukocyte to produce TNF-α upon LPS stimulation have been used as markers of immune suppression for patient selection and treatment monitoring in studies evaluating the immune enhancing effects of recombinant interferon-γ and granulocyte-macrophage colony stimulation factor in sepsis [10–12]. Here, TNF is linked to Sepsis.