The precise mechanism of NLPR3-CASP1 activation is still debated, however, considering that 1/ CTSB inhibition prevents Aβ-induced NLPR3-CASP1 activation, which reduces amyloid plaque load and improves memory in the AD brain of mouse models [106], and 2/ CTSB has been associated with several amyloids, this network provides users with a bird’s-eye view of amyloid-related literature. Here, CASP1 is linked to Alzheimer disease.