IAPP and Alzheimer disease: Reports of such co-localized amyloids include 1/ Aβ and human islet amyloid polypeptide (hIAPP) in the brain and beta-pancreatic cells [39, 40], 2/ Aβ and SAA in AD plaques [41], and 3/ Aβ and phosphorylated tau (p-tau) in synaptic terminals of AD brains [42].