Concordantly with the gene modulation results, a significant reduction in miR-214-3p, targeting BAX, and a significant up-regulation of miR-16-5p, targeting BCL2 and BIRC5, and of miR-193a-3p, targeting MCL-1, were observed in PEL (Figure 4D) and EPI (Figure 4F)-treated melanoma cells. The gene discussed is BCL2; the disease is melanoma.