Mandelalide A was a potent antiproliferative agent to NSCLC cells with wild-type LKB1 (H3122, H292, PC-9) and two of the cell lines lacking LKB1 (11-18 and NCI-H460) with GI50 values in the nanomolar range (Figure 5A,B). This evidence concerns the gene STK11 and non-small cell lung carcinoma.