STK11 and non-small cell lung carcinoma: In the present study, mandelalide A-induced phosphorylation of AMPKα (Thr172) was detected only in the LKB1-positive NSCLC cell types, however LKB1 status alone failed to predict the sensitivity of cells to the growth inhibitory effects of mandelalide A. GI50 values for five of the six NSCLC cell types tested were in the low nanomolar range, with no significant difference between LKB1-positive cells (H292, H3122 and PC-9) and LKB1-null H460 or 11-18 NSCLC cells.