Kabat et al. [19] and Ciatto et al. [16] did not find any association between MP and a higher risk of subsequent cancer, while Lewis et al. [4] reported a significantly increased relative risk (RR) of developing carcinoma in MP without atypia (3.01 [95%CI 1.10–6.55]), which was even higher when ADH or ALH was identified within the papilloma or in the surrounding parenchyma (RR = 7.01 [95%CI 1.91–17.97]). This evidence concerns the gene AVP and papilloma.