SPAG1 and immune system disorder: Considering the molecular function of the immune disease genes, we observe an accumulation of variants in genes directly or indirectly associated with ciliary transport: Coiled-coil domain containing 40 (CCDC40), dynein axonemal heavy chain 9 (DNAH9), DNAH11, PIH1 domain-containing protein 3 (PIH1D3), and SPAG1.