(4) C-type lectin receptor (CLR) signaling pathway: C-type lectin receptors such as Dectin-1, Dectin-2, and Dectin-3 are signal receptors that recognize pathogen-associated molecular patterns (PAMPs); in particular, Dectin-1 is overexpressed in hepatic fibrosis [29]. The gene discussed is DCLK3; the disease is Hepatic fibrosis.