In AFLD patients, together with alcohol-fed mouse models and AML-12 cell models, Torres et al., discovered that alcohol activated casein kinase (CK2), phosphorylated methionine acyltransferase α1 (MATα1), promoted the interaction of MATα1 with peptidyl prolyl cis-trans isomerase 1 (PIN1), and inhibited the MATα1 concentration in mitochondria. This evidence concerns the gene MAT1A and acute myeloid leukemia.