Production of SCFAs, especially butyrate;Regulates intestinal epithelial function;Performs an anti-inflammatory role in the gastrointestinal tract (blocking NF-κB and IL-8 production);Induces Treg cell accumulation in the colon;Attenuates allergic diarrhea and colitis;Triggers the secretion of IL-10 and IL-12 which attenuate inflammation. The gene discussed is NFKB1; the disease is colitis.