We also suggest a possible influence of TLR2 rs3804099 and TLR9 rs187084 on ANGPT2 prothrombotic activity in PTL, as both TLR2 and TLR9 were previously reported to have affected the ANGPT2 levels in human microvascular endothelial cells and ex-vivo RA synovial explants, as well as in HPMEC, respectively [19,66]. Here, ANGPT2 is linked to rheumatoid arthritis.