TA may share a common genetic etiology with OFC, as indicated by studies reporting more than 26 genes, including but not limited to: MSX1, PAX9, IRF6, TP63, BMP2, BMP4, WNT10A, WNT3, and AXIN2, associated with the co-occurrence of OFC [9,10]. Here, IRF6 is linked to otofaciocervical syndrome 1.