Pigment epithelium-derived factor (PEDF) has been reported to have neurotrophic, neuroprotective, and anti-cancer properties, and vascular endothelial growth factor (VEGF) has been shown to exhibit neuroprotective effects in in vitro models of ischemia and animal models of Parkinson’s disease [12,13,14,15]. Here, SERPINF1 is linked to ischemia.