PEDF has been reported to (i) exhibit neuroprotective effects in Parkinson’s disease as well as in in vitro models of motor neuron degeneration, (ii) confer anti-inflammatory properties in an animal model of diabetic retinopathy, and (iii) exhibit multifaceted anti-cancer and anti-tumor effects [29,41]. This evidence concerns the gene SERPINF1 and diabetic retinopathy.