MAPK1 and melanoma: In order to prove this, Lee, et al. [46] exposed the SK-MEL-5 and 28 cell lines to silybin and showed that it had the ability to downregulate MEK1/2, ERK2, and RSK2 proteins, thus blocking the activity of AP-1, STAT3, and NF-kB, which are responsible for the development and progression of melanoma.