By driving the expression of higher levels of cytokines (TNF-α, IL-6, IL-8, and IL-1β) in inflammatory tissues through the NF-κB pathway, F. nucleatum promotes the aggregation of tumor-associated neutrophils (TANs) and tumor-associated macrophages (TAMs), producing nitric oxide (NO) in inflammatory sites. This evidence concerns the gene CXCL8 and neoplasm.