Based on how patients with ICI-HPA were identified, all of them had secondary adrenal deficiency (ACTH deficiency), five of them also had thyroid stimulating hormone (TSH) deficiency, and six also had central hypogonadism (LH or luteinizing hormone and FSH or follicle-stimulating hormone deficiency). The gene discussed is PLOD1; the disease is hypogonadotropic hypogonadism.