CTLA4 and breast carcinoma: According to their data, a hypofractionated RT, with 24 Gy delivered in three fractions (8 Gy × three fractions), administered every other day of a week, followed by an ICI (i.e., anti-CTLA-4), resulted in an effective therapeutic scheme to switch the cold mammary carcinoma TME into a hot one (Figure 2a).