PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Meanwhile, the I148M point mutation in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene represents one of the most significant predisposing factors to NAFLD development and advanced liver damage, indicating that there is also a genomic background in NAFLD pathogenesis [82,83,84,85].