Lastly, multiple ongoing trials are targeting different pathways in the NAFL/NASH pathogenesis, such as trials of elafibranor, obeticholic acid, selonsertib, cenicriviroc, emricasan, pemafibrate, apoptosis signal-regulating kinase 1, aramchol, Toll-like receptor 4 inhibitor, fibroblast growth factor 21, acetyl-CoA carboxylase inhibitor, heat shock protein 47 and galectin-3 inhibitor [15]. This evidence concerns the gene FGF21 and metabolic dysfunction-associated steatohepatitis.