Regarding mortality, in the multivariable regression analysis, abstinence (adjusted HR, 0.25; 95% CI, 0.16-0.32; P < .001), ALDH2 rs671 polymorphism (GA/AA vs GG; adjusted HR, 1.58; 95% CI, 1.09-2.26; P = .02), Child-Pugh class B vs A (adjusted HR, 1.43; 95% CI, 1.13-2.25; P = .04) and C vs A (adjusted HR, 1.98; 95% CI, 1.18-3.31; P = .009), serum albumin (adjusted HR, 0.61; 95% CI, 0.43-0.86; P = .005), and newly developed HCC (adjusted HR, 1.68; 95% CI, 1.12-2.89; P = .01) remained significantly associated with mortality (Table 3). The gene discussed is ALDH2; the disease is hepatocellular carcinoma.