Indeed, tumor-initiation was detectable in LDHB+/+; K-rasLSL−G12D/+; p53fl/fl mice at 12 weeks of age, 4 weeks after intratracheal instillation, whereas no tumor initiation was detectable in control animals (Fig. 7c and Supplementary Fig. S7c). The gene discussed is LDHB; the disease is neoplasm.