LDHB and neoplasm: Moreover, at the end of the experiment (week 17), the average weight of lungs from LDHB−/−; K-rasLSL−G12D/+; p53fl/fl animals was significantly lower, and fewer tumor nodules were detectable compared to those from LDHB+/+; K-rasLSL−G12D/+; p53fl/fl (Fig. 7f, g), which further confirmed our conclusion that LDHB is important for NSCLC tumorigenesis.