The rate of TRAEs differs between cancer types, the dose of the ICI, the use of dual checkpoint blockade (e.g. anti-CTLA-4 combined with anti-PD-1) versus monotherapy with anti-PD-1, anti-PD-L1, or anti-CTLA-4, and in combination with other therapies, such as chemotherapy, anti-VEGF, or tyrosine-kinase inhibitors (TKIs). This evidence concerns the gene CTLA4 and cancer.