To investigate whether retinoschisin affects the potassium ion currents mediated by the Kv channels, we performed patch-clamp analyses using the retinal human retinoblastoma cell line Y-79, endogenously expressing Kv2.1, Kv8.2 (Fig. 6a), ATP1A3, and ATP1B2 [16], but not retinoschisin. Here, RS1 is linked to retinoblastoma.