Notably, we also evaluated the expression levels of validated target genes in the TCGA-LUAD dataset, compared to matched TCGA and GTEx normal data (Fig. 5B), and found that seven genes (ADM, CDKN1A, CCN2, DICER1, FLT1, JAG1, and TGM2) were significantly down-regulated in the tumor, while STAT1 was the only up-regulated one. Here, CCN2 is linked to neoplasm.