The IHC analysis performed on a cohort of NSCLC patients, characterized by different expression levels of APE1, confirmed a good correlation existing in the expression of four (i.e., DICER1, TGM2, FLT1, and JAG) out of seven genes, hypothetically regulated by APE1 through specific miRNAs, except for CCN2, CDKN1A, and ADM. This evidence concerns the gene CCN2 and non-small cell lung carcinoma.