The evaluation of the impaired expression of DICER1 upon APE1 dysregulation (both silencing or overexpression) was confirmed in another lung cancer cell line, the H358 cell line (Fig. S6) and cancer cell lines of different origin, i.e., JHH-6 (Fig. 7C), HeLa (Fig. 7D), as well as in non-cancer APE1-KO mouse lymphocytes (CH12F3) [27] (Fig. 7E and Fig. S6), supporting the notion that a common regulatory mechanism is possibly responsible for the regulation of the miRNA processing mechanism. This evidence concerns the gene APEX1 and lung cancer.