IL6 and neoplasm: Microbial stimulations, including lipopolysaccharides as well as cytokines related to Th1 helper cells like interferon-γ can promote M1 polarization of macrophages, which exert pro-inflammatory, tumor resistance as well as microbicidal effects due to their ability of antigen presentation and higher yield of IL-6, IL-23 as well as IL-12, along with high level of secretion of reactive oxygen intermediates and NO [38–41].