The results suggested that lower levels of circ‐TNPO3 were associated with ccRCC of higher WHO/ISUP grade (I–II [n = 84] vs. III–IV [n = 26], p < .01), more advanced tumour T stage (T1a–T1b [n = 86] vs. T2a–T4 [n = 24], p < .01) and distant metastasis (Yes) (metastasis [No] [n = 96] vs. metastasis [Yes] [n = 14], p < .05) (Figure 1E–G). This evidence concerns the gene TNPO3 and neoplasm.