In summary, our data suggested that SERPINH1 functions as the target of circ‐TNPO3/IGF2BP2 and SERPINH1‐SNAIL/SLUG axis may be required for circ‐TNPO3‐mediated suppression of ccRCC cell migration. This evidence concerns the gene SERPINH1 and nonpapillary renal cell carcinoma.