In addition to the role of miR‐124 in HSP through the targeting of SP or GluA2, there is also evidence that miR‐124 negatively regulates synaptic transmission, LTP, and spine density through the targeting of tyrosine‐protein phosphatase non‐receptor type 1 (PTPN1) that regulates GluA2 synaptic insertion (Wang et al, 2018), and of the transcription factors Zif268 (Yang et al, 2012) and CREB1 (Wang et al, 2016b), with possible implications in spatial learning, epilepsy, and Alzheimer's disease. This evidence concerns the gene TFF2 and early-onset autosomal dominant Alzheimer disease.