TRPC6 and major depressive disorder: The TRPC6 agonist (hyperforin) could recover the decreased TRPC6 protein expression in the hippocampus in a rat depression model and reduced the number of denatured neurons; moreover, the impaired spatial cognitive ability detected by Morris water maze was rescued and rats’ sucrose solution intake was higher in the depression group treated by hyperforin (Liu Y. et al., 2015).