Conversion of fibroblast growth factor receptor 2b (FGFR2b) to FGFR2c induces EMT and represses nuclear factor-erythroid 2 (NFE2) like basic leucine zipper (bZIP) transcription factor 2 (NRF2)-mediated detoxification of ROS, which leads to the progression of cancer (Katoh and Katoh, 2009). The gene discussed is NFE2; the disease is cancer.