SIRT2 and diabetic neuropathy: SIRT2, an NAD+-dependent deacetylase in the sirtuin family, has been implicated in multiple biological processes including tumor suppression, neurodegenerative disorders, lipid and glucose homeostasis, and longevity.15–19 SIRT2 is found in both the nucleus and cytoplasm,20,21 and its localization and expression are regulated through diet, oxidative stress,20,22 and cell cycle progression.23 Pharmacologic activation of SIRT2 by resveratrol24 and nicotinamide riboside (NR)25 has been shown to alleviate diabetic neuropathy in animal models.26