By analyzing the expression quantitative trait loci (eQTL) dataset from GTEx Portal, we found that rs61753730 showed eQTL regulation with allele-specific significance on FZD6 mRNA expression, especially in the cerebellum (p = 1.3 × 10–5), a brain region implicated in depression (Depping et al., 2018). This evidence concerns the gene FZD6 and major depressive disorder.