By pharmacologically blocking Alpha2delta1/2 subunits of voltage-gated calcium channels (Gee et al., 1996; Gong et al., 2001), gabapentinoids augment mechanisms of structural plasticity and facilitate the regeneration of ascending sensory and descending motor pathways following SCI and ischemic stroke in adult mice (Tedeschi et al., 2016, 2022; Sun et al., 2020). Here, CACNA2D1 is linked to ischemic stroke.