Serval regulatory proteins of mitophagy are found to be alerted in AD patients such as presenilin 1 (PS1), phosphatase and PINK1, Bcl-2 associated athanogene 3 (BAG-3), p62, Microtubule-associated protein 1A/1B-LC3 and TANK-binding kinase 1 (TBK1; Xie et al., 2022). The gene discussed is PSEN1; the disease is Alzheimer disease.