The induction of mitophagy by NAD + precursors could be a favorable therapeutic strategy for AD treatment because NAD + works as a cofactor for several proteins that regulate the autophagy/mitophagy pathway, including SIRT, PARP (poly [ADP-ribose] polymerase) and SARM1 (sterile alpha and TIR motif-containing 1) (Fang et al., 2019). This evidence concerns the gene SARM1 and Alzheimer disease.