Specifically, mutations in a number of chromatin regulators have been associated with neurodevelopmental disorders such as Rett syndrome (MECP2), intellectual disability (CHD1, CHD2, CHD7, CHD8, ATRX, and KDM5C), epilepsy (CHD1, CHD2, CHD7, CHD8) (Consortium et al., 2013), and ASD (MECP2, CHD1, CHD2, CHD3, CHD7, CHD8, MBD1, MACROD2, H2AFY, ARID1B, SMARCC1, SMARCC2, and JMJD1C) (reviewed in LaSalle, 2013). Here, CHD2 is linked to Down syndrome.