SLC12A2 and epilepsy: It is worth mentioning that the Slc12a2 KO mouse is viable (Delpire et al., 1999; Dixon et al., 1999; Flagella et al., 1999); however, the loss of the NKCC1 protein causes deficits in neuronal proliferation (Magalhães and Rivera, 2016) and exacerbates the severity of a mouse model of epilepsy (Hampel et al., 2021), amongst other issues.