LPIN1 and Cognitive impairment: Phosphatidate phosphatase LPIN1 plays an important role in adipocyte differentiation and lipid metabolism; decreased Lpin1 expression is correlated with insulin resistance, and mutations in Lpin1 determine cognitive impairment in mice with fatty liver dystrophy (Ryu et al., 2009; Chen et al., 2012; Shang et al., 2020; Xie et al., 2020).