We have previously demonstrated that CRISPR/Cas9-mediated targeting of the Plaur gene inhibits Neuro2a neuroblastoma cell proliferation, leading to downregulation of full-length Ntrk3 messenger RNA (mRNA), which encodes tropomyosin receptor kinase C (TrkC), a receptor that is involved in p38/Akt signaling pathway (Rysenkova et al., 2018). This evidence concerns the gene PLAUR and neuroblastoma.