Considering that Plaur polymorphisms in humans are associated with cognitive disorders (Campbell et al., 2008) in mice with behavioral dysfunction and epilepsy (Powell et al., 2003), apoptosis of neuronal cells in vitro (Rysenkova et al., 2018), as well as Plaur gene knockout leads to impaired brain formation (Eagleson et al., 2011), we hypothesize that these “protective” uPAR effects on brain neurons may be implemented via Plaur-miR1 and its target Mef2d. Here, MEF2D is linked to cognitive disorder.