BDNF and mood disorder: Interestingly, Dincheva et al. (2017) demonstrated that BDNF Met/Met mice showed normal behavior at postnatal day 30 (P30), which is an early adolescent period, but anxiety behavior was increased in young adults (at P60), indicating that disrupted BDNF signaling due to the BDNF polymorphism mostly affected behaviors related to mood disorders during the adolescent period.