For instance, mimicking DEPDC5 (DEP containing 5 domain) loss-of-function in zebrafish recapitulates critical hallmarks of brain disorders caused by mutations in this gene, such as epileptiform discharges and exacerbated mTOR signaling (de Calbiac et al., 2018; Swaminathan et al., 2018). This evidence concerns the gene DEPDC5 and brain disorder.