In this context, our group pioneered the generation of several models of CNS genetic disorders, caused by mutations in gabra1 (Samarut et al., 2018), gabrg2 (Liao et al., 2019), depdc5 (Swaminathan et al., 2018), glra1 (Samarut et al., 2019), or gldc (Riche et al., 2018), and these mutants display clinically-relevant phenotypes such as seizures, ataxic motor phenotypes or hypotonia. Here, GABRA1 is linked to hereditary disease.