Conjugation of a CD133 monoclonal antibody to a phototoxic phthalocyanine NIR dye IR700 allowed for specific targeting and imaging of CD133+ glioma stem cells and treatment using NIR photoimmunotherapy to cause tumor shrinkage and cell death in a murine intracranial orthotopic model of glioma (Jing et al., 2016). This evidence concerns the gene PROM1 and central nervous system cancer.