VEGFA and neoplasm: MRI with and without the use of Gd contrast allows for the delineation of higher grade primary brains tumors such as glioblastoma, secondary brain metastases, and extra-axial tumors such as meningiomas, due to the nature of these tumors to secrete vascular endothelial growth factor which causes the formation a tortuous and leaky BBB around the tumor which allows for the extravasation of contrast agent, leading to visualization of the tumor mass on subsequent T1-weighted MRI sequences (Jain et al., 2007; George et al., 2018).