EGFR and central nervous system cancer: Other researchers have synthesized Gd-chelated-IONPs functionalized with interleukin-13 (Li et al., 2015), antibodies against the mutant epidermal growth factor receptor (EGFRvIII) (Hadjipanayis et al., 2010), or cyclic arginine-glycine-aspartic acid (cRGD) peptides (Booth et al., 2017), to enhance glioma targeting for enhanced imaging in preclinical animal models of glioma.