An engineered resveratrol-loaded fibrous scaffolds were fabricated via electrospinning method. The polycaprolactone embedded resveratrol (PCL-R) scaffolds demonstrated decreased inflammatory cell infiltration, improved collagen ECM secretion, and blood vessel network formation following myocardial infarction (MI). Also, the immunofluorescence analysis disclosed resveratrol-loaded scaffolds promote increased expression of cTnT, Cx-43, Trx-1, and VEGF proteins. This evidence concerns the gene TNNT2 and myocardial infarction.