According to TCGA genomic features, various molecular classifications have been established to date [24–29], including microsatellite instability/mismatch repair (MSI/MMR) status, programmed death-ligand 1 (PD-L1) expression, tumor mutational burden (TMB) status, neurotrophic tropomyosin-related kinase fusions, and tumor Epstein–Barr virus, which revolutionizes the oncology therapy landscape. Here, CD274 is linked to neoplasm.