In parallel, a link to angiogenesis is implied by the fact that Sp1 overexpression is associated with the upregulation of VEGF in gastric cancer, and two targets of miR-218 have been identified: Angiopoietin-2 and ROBO1 (roundabout guidance receptor 1), and their downregulation result in a reduction of tumor proliferation, invasion, and angiogenesis [12]. This evidence concerns the gene ROBO1 and gastric cancer.