ATP13A2 and Parkinson disease: Scholars have studied PD patients with ATP13A2 mutations and found the following changes related to lysosomal function in these patients: (I) abnormal elevation of the lysosomal pH (Vidyadhara et al., 2019), (II) increased lysosomal permeability (Rinaldi et al., 2015), and (III) impaired cathepsin maturation (Matsui et al., 2013).