In PD caused by mutations in the ATP13A2 gene, abnormal lysosomal function impairs autophagy, resulting in the inability of dopaminergic neurons to clear misfolded and abnormally aggregated α-synuclein, which suggests that autophagy inhibition is one of the core pathogenic processes of PD (Colasanti et al., 2014; Lopes da Fonseca and Outeiro, 2014). Here, SNCA is linked to Parkinson disease.