In vitro studies suggest the existence of a positive feedback loop between IL-1β and P2X7R (Narcisse et al., 2005), which may explain overexpression of both gene transcripts in the hippocampus and temporal neocortex of this MTLE-HS patients cohort (this study; see also Leal et al., 2017). This evidence concerns the gene IL1B and histiocytic sarcoma.