Similarly, Gal-3 levels were increased in the serum and brain of high-fat diet/streptozotocin-induced diabetic rats (Yin et al., 2020), whereas the MCP attenuated inflammation, oxidative stress, and cognitive impairment in diabetic rats and also in high glucose-stimulated BV-2 microglial cells (Yin et al., 2020). This evidence concerns the gene LGALS3 and Cognitive impairment.