The application of recombinant Gal-3 after stroke increased expression of Ym1, diminished iNOS expression, and lead to a significant increase of an anti-inflammatory cytokine (IL-4) and a reduction in proinflammatory cytokines (TNF-α, IL-1β, IFN-γ, and IL-17) in ipsilateral brain regions. This evidence concerns the gene LGALS3 and stroke disorder.