The amyloid-β (Aβ) and lipopolysaccharide (LPS)-induced increases in glycolytic flux in cultured microglia (Baik et al., 2019; McIntosh et al., 2019) have been attributed to mTOR-HIF-1α pathway activation (Baik et al., 2019) or iron accumulation in microglia (McIntosh et al., 2019) and these changes translated into 2 models of AD, 5XFAD and APP/PS1 mice (Baik et al., 2019; McIntosh et al., 2019). Here, APP is linked to Alzheimer disease.