APP and Alzheimer disease: Similar up- and down-regulated transcripts were observed in models of disease, particularly Alzheimer’s disease (AD), including APP/PS1 mice (Holtman et al., 2015; Krasemann et al., 2017; Kang et al., 2018; Guillot-Sestier et al., 2021), 5XFAD mice (Keren-Shaul et al., 2017) and AppNL–G–F mice (Sala Frigerio et al., 2019).