BRCA1-mutated breast cancers tend to have a high histologic grade and be classified as triple-negative breast cancer (TNBC), while tumors associated with BRCA2 PVs are associated with estrogen receptor (ER)-positive and HER2-negative subtype, but with a tendency toward a higher proportion of TNBC with increasing age (4). Here, BRCA1 is linked to breast carcinoma.