Our study aims at investigating the prevalence of HIV patients with HBV/HCV triple infection and those with HIV/HCV or HIV/HBV co-infection along with the prevalence of HCC in patients with co-infections or triple infections with these viruses and demonstrates the relationship between the incidence of HCC with different CD4 counts stratified by hepatitis B or hepatitis C positivity or both. This evidence concerns the gene CD4 and coinfection.