CD44 and neoplasm: Through receptor-mediated endocytosis, Hyaluronic based nanoparticles are thought to be an effective strategy for delivering anticancer medicines into CD44-overexpressing tumor cells, and subsequent enzymatic breakdown results in the nanoparticles content obtaining a sustainable release through the CD44-mediated endocytosis mechanism into the lysosome [[68], [69], [70], [71]].