FAP and neoplasm: To obtain such nanoasystems, DOX and immunotherapeutic enhancer (Fe ions) immobilized on the surface of carbon dots (CDs) with modification of aminoethyl anisamide (AEAA, a targeting ligand of sigma receptor) (APCDs) were crosslinked by fibroblast activation protein-α (FAP-α)-responsive Asp-Ala-Thr-Gly-Pro-Ala peptides, followed by encapsulation of tumor microenvironment modifier (LOS) in the mesopores between carbon dots within the nanoassemblies (Fig. 8a).