Cholesteryl-6-aminohexylcarbamate methacrylated HA (cm-HA) was used to form collaboratively crosslinked nanogels (cNG) via both physical and chemical crosslinking to load DNase I and a tumor-acidity-activatable HAase (aHAase, the amino residues in HAase were shielded by the citraconic anhydride modification). Here, DNASE1 is linked to neoplasm.