PREX1 and cancer: The hypothetical role of P-Rex1 as a functional signaling platform, putatively assembling a network with receptors, kinases and phosphatases, among other signaling partners, was defined as the network of coessential signaling proteins identified in the cancer cells in which P-Rex1 was essential, and the set of signaling proteins highly coexpressed with PREX1 in patients in which their expression correlated with shorter survival.