As an integrated signaling module, the PREX1 signaling hub signature deserves further characterization in the context of LGG biology, as well as in other types of cancer, given that members of the signature consistently were found coexpressed with PREX1. Although we did not directly demonstrate a direct regulation of P-Rex1 by its potential signaling partners, knowing their identity and statistical correlation with patient survival puts the focus on them for future studies. This evidence concerns the gene PREX1 and cancer.